|
|
 |
| |
 |
| |
What
is bioinformatics? |
|
| |
Bioinformatics is the application
of information technology to manage biological information.
Computers are used to gather, store, analyze and integrate
biological and genetic information, which can then
be applied to gene-based drug discovery and development.
Biological sequence analysis has
existed as a niche on the edge of other well-established
research areas - molecular biology, physics, mathematics,
and computer science. The possibilities which lie
in using the computer as a tool in obtaining understanding
of, and manipulating, genomes and other biological
macromolecules, depend on the quality of the collaborations
which are established in the field. In the next century
it is expected that the research will have a strong
impact on conceptions of the micro and macroscopic
characters of genomes, the relation between individual
and species, and the interplay between man and the
evolutionary process.
|
|
|
 |
 |
| |
Why
bioinformatics ? |
| |
The 21st century is witnessing the
dawn of Biotechnology, which is expected to surpass
Information Technology as the new engine of the global
economy. Its products will be more important than
the fire, the wheel, or the car and will generate
more knowledge in a short period of time than history's
collective wisdom. Biotechnology is expected to alter
healthcare, agriculture, commercial and industrial
products. It is predicted, that by the middle of the
21st century, all companies will become Biotech companies
in some form or the other. One of the key driver and
enabler of this emerging technology is bioinfomatics
.
Large scale DNA arrays and other
tools of genomics and proteomics offer unique opportunities,
which will revolutionize medical research and development
in this century. Bioinformatics is a highly interdisciplinary
subject that calls for expertise in different disciplines,
such as, biology, chemistry, physics, computer science,
statistics and mathematics.
|
| |
|
|
 |
| |
What
are the opportunities in bioinformatics ? |
| |
Bioinformatics provides the integrated
approach of mining the voluminous data generated by
the HGP to identify and understand human diseases
and to develop corresponding drug and gene based therapies.
Bioinformatics will increasingly replace conventional
methodologies in the area of drug discovery and drug
delivery.
The importance of Bioinformatics
is gaining rapid acceptance and bioinformatics groups
comprising of computational biologists, computer scientists
as well as computer engineers are being constituted
at universities, pharmaceuticals and biotechnology
companies.
The worldwide Bioinformatics market is mostly localized
in the United States and Europe. The market value
of products and services is valued at over US$ 2 billion.
Predominantly, there are two application areas - Agriculture
and Pharmaceuticals. While Agricultural Bioinformatics
depends on the whole genome sequencing of plants,
the pharmaceutical sector relies on the success of
the Human Genome Sequencing efforts along with the
sequencing of the mouse and other model organisms
for comparative genomic efforts and for clinical trials
in model organisms.
Given the nascent nature of this industry and the
large number of private players in the field, the
current market for external products and services
is hard to determine. Surveys of the 50 or so bioinformatics
tool and database companies by market research groups
like Frontline and Frost & Sullivan, for example,
put the current market for bioinformatics databases,
products and services at roughly $300 million, with
about half of the annual sales by data suppliers and
half of the sales by tool/IT providers of various
kinds. These groups and other industry observers believe
that this market could grow to $1.5-2.0 billion over
the next five years. These estimates exclude some
significant internal spending on IT infrastructure
by pharmaceutical and biotechnology companies that
is bioinformatics related, and could be as large as
$ 2.0 billion + annually. As discussed above, also
excluded are most of the project-based R&D collaborations
between 'pharma/ag-bio' companies and genomics companies
that include bioinformatics "content," which total
well over $1.0 billion on a cumulative basis over
the past 3-5 years
|
| |
|
|
 |
| |
What
is HGP? |
| |
Started formally in 1990, the U.S.
Human Genome Project is a 13-year effort coordinated
by the U.S. Department of Energy and the National
Institutes of Health. The project originally was planned
to last 15 years, but rapid technological advances
have accelerated the expected completion date to 2003.
Project goals are to
identify
all the approximate 30,000 genes in human DNA,
determine
the sequences of the 3 billion chemical base pairs that
make up human DNA,
store
this information in databases,
improve
tools for data analysis, transfer related technologies
to the private sector, and
address
the ethical, legal, and social issues (ELSI) that may
arise from the project. |
| |
|
|
 |
| |
What
is Genome and Proteome Analysis? |
| |
The total constitution of genes of
and organism is called Genome, and the total protein
composition of a cell is called as Proteome. After
the HGP these two fields have become the focus of
all the pharmaceutical and Biotech companies. The
genome analysis deals with the study of the genomes
of different organisms, annotation of their genes,
gene expression and gene regulation patterns, mutation
analysis etc., Proteome analysis deals with the study
of the proteins and their expression patterns in different
organisms at different developmental stages and pathologic
stages.
|
| |
|
|
 |
| |
Why
should a science professional do the Bioinformatics
course? |
| |
With the bioinformatics field growing
so rapidly, it has almost become a mandate for every
science student to be well equipped with computational
techniques also. It is estimated that by 2050 all
the industries in one way or the other become Biotech
companies. Considering this fact, this course has
been designed to suit professionals from different
backgrounds to endeavor their interests and make a
career in Bioinformatics. The Bioinformatics course
manly aims at an insight into the understanding and
deciphering of the scientific data available which
involves professionals in several fields such as Biology,Chemistry,Mathematics,Statistics
and Information Technology.
|
| |
|
|
 |
| |
What
is the difference between Protein Modeling & Rational
Drug Design and Genome and Proteome Analysis?
|
| |
Protein Modeling & Rational Drug
Design mainly emphasizes on protein modeling and rational
drug design and discovery which are of significant
interests to the pharmaceutical and biotech companies
as these insilico techniques hasten the process of
drug discovery. Genome and Proteome Analysis deals
with genome and proteome analysis which are of pivotal
interests especially after post genomic era, both
in the industry and academics. This also deals with
invitro experiments.
|
| |
|
|
 |
| |
Are
IT skills a pre- requisite for Genome and Proteome Analysis
and Protein Modeling & Rational Drug Design courses?
|
| |
Both the courses are designed in
such a way that a professional with science background
would get an understanding of IT concepts necessary
for a Bioinformatics career and vice versa.
|
| |
|
|
 |
| |
Does
this course help for pursing higher education?
|
| |
Yes,this course would definitely
be a very valuable asset for pursuing higher education.
They could work in relevant science spheres and implement
bioinformatics in the related disciplines.
|
| |
|
|
|
|
|