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The Human Genome Project has revealed the
existence of approximately 40,000 genes, some of which could
be used as new targets for drug design purposes. There is
a tremendous potential in the study of their functional
genomics and the corresponding protein structure vis-à-vis
drug design. Almost all the leading pharmaceutical and biotech
companies are focusing their efforts to discover new targets
and to design new and better drugs.
The aim of this course is to impart training in the basic
principles of protein structure, to generate the three dimensional
structure of a protein from its amino acid sequence and
its utilization in the structure based drug design studies.
The course covers computational approaches to the drug discovery
& design processes such as analogue based designs and pharmacophore
based studies that are very useful in the absence of 3D-structural
information of relevant targets.
There is a huge shortage in manpower with the requisite
skill sets to perform such studies. This course tries to
address such a need by imparting a comprehensive training
in Protein Modeling and Rational Drug Discovery techniques.
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